The core unit bioinformatics (CUBI), headed by Dieter Beule, comprises experts, who face the challenge of managing rapidly increasing amounts of complex molecular data and provide solutions and analyses that are usable for biomedical research and clinical application. The CUBI team focuses on method development and algorithms for efficient, reproducible, and reliable omics data processing and interpretation as well as new access data technologies. The omics data analysis comprises the areas of rare disease genetics, cancer genomics, functional genomics, single cell transcriptomics, as well as metabolomics and proteomics. CUBI already developed systems for omics data access and retrieval (SODAR) that allows handling of proteomics, metabolomics and genomics raw data with related pseudonymised metadata and in addition, processing results with related log-files.
As part of the MSTARS consortium, Dieter Beule and the CUBI team design new metadata models for the new data types derived from e.g. MALDI Imaging or CyTOF experiments. Subsequently, they establish data import pipelines for the new technologies into SODAR, followed by the validation of these pipelines to guarantee high data quality and consistency. The team of Dieter Beule similarly supports the data analyses of the different work packages. In addition, they perform data integration of omics data sets to retrieve signatures with biomedical relevance and compare the results with existing and validated methods for treatment decisions. In the long run, the usability of the generated information for the molecular tumor conference will be evaluated.